Potassium Fluoride → HCID 86687909, compound

HRID 1400062Notes

Reaction equation

HRID 1400062 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:11]#[C:12][Si](CC)(CC)CC)=[C:6]([CH2:8][C:9]#[N:10])[CH:7]=1.[F-].[K+]>CO>[C:11]([C:5]1[CH:4]=[CH:3][C:2]([F:1])=[CH:7][C:6]=1[CH2:8][C:9]#[N:10])#[CH:12]

Participants

4

Reactant 2

HCID 522689Potassium FluorideHCID 66764470HCID 66764470, compound

Product 1

HCID 86687909HCID 86687909, compoundYield 99.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-(5-Fluoro-2-((triethylsilyl)ethynyl)phenyl)acetonitrile (1.044 g, 3.82 mmol) is dissolved in methanol (38.2 ml), and potassium fluoride (0.887 g, 15.27 mmol) is added. The yellowish solution is stirred at RT for 48 hours. The solvent is subsequently removed in vacuo, and the residue is taken up with water (30 ml). The usual extraction and drying method described under 1) gives 606 mg of the title compound in quantitative yield. (3.81 mmol);

Workup

  1. customThe solvent is subsequently removed in vacuo
  2. extractionThe usual extraction
  3. customdrying method

Sources & evidence

ORD record
ord-ea01792adf9c4ca1a907304d7d1b71b2
Source dataset
uspto-grants-2014_12
Patent number
US08906916B2

Reaction notes

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