Hydrochloric Acid → HCID 71226271, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of Example 1D (5.3 g, 20.3 mmol) in methanol (33 mL) and water (15 mL) was added a aqueous solution of sodium hydroxide (3.2 g, 80 mmol in 4 mL of water) and the mixture was heated at 65° C. for 16 hours. The mixture was cooled to room temperature, acidified to pH=4 with 4N hydrochloric acid. The solid was filtered to afford Example 1E which was used in next step without further purification.

Provenance & Evidence