Hydrochloric Acid → HCID 71226271, compound

HRID 1400069Notes

Reaction equation

HRID 1400069 reaction equation
[CH3:1][C:2]1[N:3]([C@H:8]2[CH2:15][C@@:14]3([C:16]([O:18]C)=[O:17])[C@H:10]([CH2:11][CH2:12][CH2:13]3)[CH2:9]2)[C:4]([CH3:7])=[CH:5][CH:6]=1.[OH-].[Na+].Cl>CO.O>[CH3:1][C:2]1[N:3]([C@H:8]2[CH2:15][C@@:14]3([C:16]([OH:18])=[O:17])[C@H:10]([CH2:11][CH2:12][CH2:13]3)[CH2:9]2)[C:4]([CH3:7])=[CH:5][CH:6]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 71226046HCID 71226046, compound

Product 1

HCID 71226271HCID 71226271, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Conditions

Temperature
65 °C

Procedure

To a solution of Example 1D (5.3 g, 20.3 mmol) in methanol (33 mL) and water (15 mL) was added a aqueous solution of sodium hydroxide (3.2 g, 80 mmol in 4 mL of water) and the mixture was heated at 65° C. for 16 hours. The mixture was cooled to room temperature, acidified to pH=4 with 4N hydrochloric acid. The solid was filtered to afford Example 1E which was used in next step without further purification.

Workup

  1. temperatureThe mixture was cooled to room temperature
  2. filtrationThe solid was filtered
  3. customto afford Example 1E which
  4. customwas used in next step without further purification

Sources & evidence

ORD record
ord-1970057ccb114405994b4a4a3c75dc48
Source dataset
uspto-grants-2014_12
Patent number
US08906911B2

Reaction notes

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