Sodium Hydroxide → HCID 178516045, compound

HRID 1400083Notes

Reaction equation

HRID 1400083 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][CH:3]=1.[OH-:12].[Na+]>O>[F:9][C:8]([F:11])([F:10])[C:5]1[N:6]=[N:7][C:2]([OH:12])=[CH:3][CH:4]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 282425263-Chloro-6-(trifluoromethyl)pyridazine

Product 1

HCID 178516045HCID 178516045, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 6-chloro-3-trifluoromethylpyridazine (10 g, 54. 9 mmol) (prepared by following the procedure described in Goodman, A. J.; Stanforth, S. P.; Tarbit B. Tetrahedron 1999, 55, 15067-15070) and sodium hydroxide (8 g, 0.7 mmol) in water (150 ml) was stirred at reflux for 5 h. After this period, the solvent was evaporated in vacuo and the crude product dried at 60° C. under vacuum for 16 h. to yield D3, mixed with sodium chloride, (16.2 g,>100%) as a solid. C5H3F3N2O requires 164; Found 165 (MH+).

Workup

  1. customprepared
  2. temperatureat reflux for 5 h
  3. waitAfter this period
  4. customthe solvent was evaporated in vacuo
  5. dry with materialthe crude product dried at 60° C. under vacuum for 16 h.

Sources & evidence

ORD record
ord-0a7f73667a5345b9b788d2edb4599339
Source dataset
uspto-grants-2014_12
Patent number
US08906921B2

Reaction notes

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