Sodium Hydroxide → HCID 178516045, compound

Participants

Reaction Steps

A mixture of 6-chloro-3-trifluoromethylpyridazine (10 g, 54. 9 mmol) (prepared by following the procedure described in Goodman, A. J.; Stanforth, S. P.; Tarbit B. Tetrahedron 1999, 55, 15067-15070) and sodium hydroxide (8 g, 0.7 mmol) in water (150 ml) was stirred at reflux for 5 h. After this period, the solvent was evaporated in vacuo and the crude product dried at 60° C. under vacuum for 16 h. to yield D3, mixed with sodium chloride, (16.2 g,>100%) as a solid. C5H3F3N2O requires 164; Found 165 (MH+).

Provenance & Evidence