Sodium Carbonate → HCID 178451467, compound

HRID 1400103Notes

Reaction equation

HRID 1400103 reaction equation
[C:1]([C:3]1[CH:4]=[CH:5][C:6]([N:9]2[CH:14]3[CH2:15][CH2:16][CH:10]2[CH2:11][N:12]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:13]3)=[N:7][CH:8]=1)#[N:2].Cl.[NH2:25][OH:26].C(=O)([O-])[O-].[Na+].[Na+]>C(O)C.O>[OH:26][NH:25][C:1]([C:3]1[CH:4]=[CH:5][C:6]([N:9]2[CH:10]3[CH2:16][CH2:15][CH:14]2[CH2:13][N:12]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:11]3)=[N:7][CH:8]=1)=[NH:2]

Participants

6

Reactant 3

HCID 10340Sodium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 86702033HCID 86702033, compound

Product 1

HCID 178451467HCID 178451467, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Conditions

Temperature
90 °C

Procedure

The product of step b) (7.6 g) is dissolved in 75 ml of ethanol, and a solution of 3.36 g of hydroxylamine hydrochloride dissolved in 38 ml of water is added, followed by addition of 5 g of sodium carbonate. The mixture is stirred at 90° C. for 4 hours. The resulting mixture is cooled and filtered. 8 g of the title compound are obtained in the form of a white solid.

Workup

  1. additionis added
  2. temperatureThe resulting mixture is cooled
  3. filtrationfiltered

Sources & evidence

ORD record
ord-b7cd6e436ec34ec5aa7326b28b383388
Source dataset
uspto-grants-2014_12
Patent number
US08906924B2

Reaction notes

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