Sodium Hydroxide → HCID 52939425, compound

HRID 1400134Notes

Reaction equation

HRID 1400134 reaction equation
[NH2:1][C:2]1[N:11]=[C:10]([C:12]([N:14]2[CH2:22][C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH2:15]2)=[O:13])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:23]3([C:26]([O:28]CC)=[O:27])[CH2:25][CH2:24]3)[CH:8]=2)[N:3]=1.[OH-].[Na+]>O1CCCC1>[NH2:1][C:2]1[N:11]=[C:10]([C:12]([N:14]2[CH2:15][C:16]3[C:21](=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH2:22]2)=[O:13])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:23]3([C:26]([OH:28])=[O:27])[CH2:24][CH2:25]3)[CH:8]=2)[N:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 52939424HCID 52939424, compound

Product 1

HCID 52939425HCID 52939425, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
23 °C

Procedure

400 mg of ethyl 1-[2-amino-4-(isoindoline-2-carbonyl)quinazolin-6-yl]cyclopropanecarboxylate are dissolved in 14 ml of tetrahydrofuran, and 3.5 ml of 2N sodium hydroxide solution are added. The mixture is stirred at 23° C. for 12 h, evaporated to dryness in vacuo, taken up in 10 ml of water and adjusted to pH 2 using 1 ml of 25% hydrochloric acid. The resultant precipitate is filtered off and dried in vacuo. Yield: 250 mg (67%) of 1-[2-amino-4-(isoindoline-2-carbonyl)quinazolin-6-yl]cyclopropanecarboxylic acid;

Workup

  1. customevaporated to dryness in vacuo
  2. filtrationThe resultant precipitate is filtered off
  3. customdried in vacuo

Sources & evidence

ORD record
ord-6fc223289cc04f0a9a38ab581c29beb0
Source dataset
uspto-grants-2014_12
Patent number
US08906930B2

Reaction notes

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