HCID 67153985, compound → HCID 67154019, compound

Participants

Reaction Conditions

Reaction Steps

2.4 g of ethyl 2-(4-aminophenyl)-2-(3,3-difluoroallyl)-5,5-difluoropent-4-enoate are dissolved in 30 ml of tetrahydrofuran, 1 g of 5% Pd/C (52.3% of water) is added, and the mixture is stirred at 23° C. under a hydrogen atmosphere for 1 h. After aeration, the solid material is filtered off, and the filtrate is evaporated to dryness in vacuo. Yield: 2.3 g (99%) of ethyl 2-(4-aminophenyl)-2-(3,3-difluoropropyl)-5,5-difluoropentanoate; LC-MS retention time: 2.09 min.

Provenance & Evidence