HCID 67153985, compound → HCID 67154019, compound

HRID 1400158Notes

Reaction equation

HRID 1400158 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH2:19][CH:20]=[C:21]([F:23])[F:22])([CH2:14][CH:15]=[C:16]([F:18])[F:17])[C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:4][CH:3]=1>O1CCCC1.[Pd]>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([CH2:14][CH2:15][CH:16]([F:17])[F:18])([CH2:19][CH2:20][CH:21]([F:22])[F:23])[C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 67153985HCID 67153985, compound

Product 1

HCID 67154019HCID 67154019, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
23 °C

Procedure

2.4 g of ethyl 2-(4-aminophenyl)-2-(3,3-difluoroallyl)-5,5-difluoropent-4-enoate are dissolved in 30 ml of tetrahydrofuran, 1 g of 5% Pd/C (52.3% of water) is added, and the mixture is stirred at 23° C. under a hydrogen atmosphere for 1 h. After aeration, the solid material is filtered off, and the filtrate is evaporated to dryness in vacuo. Yield: 2.3 g (99%) of ethyl 2-(4-aminophenyl)-2-(3,3-difluoropropyl)-5,5-difluoropentanoate; LC-MS retention time: 2.09 min.

Workup

  1. filtrationAfter aeration, the solid material is filtered off
  2. customthe filtrate is evaporated to dryness in vacuo

Sources & evidence

ORD record
ord-9fd7e904d81f4a47acf814b1981bdbf5
Source dataset
uspto-grants-2014_12
Patent number
US08906930B2

Reaction notes

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