Hydrochloric Acid → HCID 67540104, compound

HRID 1400218Notes

Reaction equation

HRID 1400218 reaction equation
[NH:1]=[C:2]1[C:6]2=[N:7][CH:8]=[CH:9][CH:10]=[C:5]2[C:4](=[O:11])[N:3]1[CH2:12][C:13](=O)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.Cl.[OH-:22].[Na+]>O>[C:14]1([C:13]2[NH:1][C:2]([C:6]3[N:7]=[CH:8][CH:9]=[CH:10][C:5]=3[C:4]([OH:22])=[O:11])=[N:3][CH:12]=2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 67538782HCID 67538782, compound

Product 1

HCID 67540104HCID 67540104, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

To the suspension of 7-imino-6-(2-oxo-2-phenylethyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one (825 mg, 3.11 mmol) in 1N NaOH (6.22 ml) 40 ml of water were added, and the reaction mixture heated to reflux for 1.5 hours. After cooling to room temperature the mixture was diluted with 100 ml of water, and the pH adjusted to 2-3 by addition of 2N HCl. The resulting precipitate was filtered off and dried to give 414 mg of the title compound as solid; ESI-MS [M+W]: 266.1.

Workup

  1. additionwere added
  2. temperaturethe reaction mixture heated
  3. temperatureto reflux for 1.5 hours
  4. filtrationThe resulting precipitate was filtered off
  5. customdried

Sources & evidence

ORD record
ord-f8790cb952324746918501b494cf03ef
Source dataset
uspto-grants-2014_12
Patent number
US08906941B2

Reaction notes

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