Hydrochloric Acid → Dichlorprop-P

HRID 1400243Notes

Reaction equation

HRID 1400243 reaction equation
[OH-].[K+].[Cl:3][C:4]1[CH:17]=[C:16]([Cl:18])[CH:15]=[CH:14][C:5]=1[O:6][C@H:7]([CH3:13])[C:8]([O:10]CC)=[O:9].Cl>O.CCO>[Cl:3][C:4]1[CH:17]=[C:16]([Cl:18])[CH:15]=[CH:14][C:5]=1[O:6][C@H:7]([CH3:13])[C:8]([OH:10])=[O:9]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 12375251ethyl (R)-2-(2,4-dichlorophenoxy)propionate2×

Product 1

HCID 119435Dichlorprop-P

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

To a solution of KOH (2.48 g, 44.2 mmol, 15 eq) in H2O (12 mL) was added ethyl (R)-2-(2,4-dichlorophenoxy)propionate (compound 9a; 0.80 g, 3.05 mmol) in EtOH (12 mL) at room temperature. The solution was stirred for 4 hours, and then acidified with concentrated aqueous HCl (pH 3). The resulting solid was filtered, rinsed with water, and dried to yield a white powder which was used without further purification.

Workup

  1. filtrationThe resulting solid was filtered
  2. washrinsed with water
  3. customdried
  4. customto yield a white powder which
  5. customwas used without further purification

Sources & evidence

ORD record
ord-0e5d48377b434c5e97ff792856c1261f
Source dataset
uspto-grants-2014_12
Patent number
US08906945B2

Reaction notes

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