HCID 86709749, compound → 2-[(1-Chloronaphthalen-2-yl)oxy]ethanaminium chloride
Reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[O:12][CH2:13][CH2:14][NH:15]C(=O)OC(C)(C)C>C(OCC)C.Cl.O1CCOCC1>[Cl-:1].[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[O:12][CH2:13][CH2:14][NH3+:15]Participants
5
Reactant 1
Product 1
Reagents, catalysts & solvents 3
Conditions
- Temperature
- 0 °C
Procedure
To a cooled (0° C.) single necked flask containing a solution of tert-butyl {2-[(1-chloronaphthalen-2-yl)oxy]ethyl}carbamate in 4 mL of ethyl ether, 5 mL of 4 M HCl solution in dioxane were added. The resulting mixture was stirred at room temperature for 18 h. The reaction mixture was concentrated under reduce pressure to afford 2-[(1-chloronaphthalen-2-yl)oxy]ethanaminium chloride as a white solid (92% yield) which was pure by TLC and NMR analysis.
Workup
- additionwere added
- concentrationThe reaction mixture was concentrated
Sources & evidence
- ORD record
- ord-bd13e08fbece4507a756acc428eab7d0
- Source dataset
- uspto-grants-2014_12
- Patent number
- US08906946B2
Reaction notes
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