Hydrochloric Acid → HCID 68151396, compound

HRID 1400293Notes

Reaction equation

HRID 1400293 reaction equation
[F:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[O:12][CH2:13][CH2:14][NH:15]C(=O)OC(C)(C)C.[ClH:23]>C(OCC)C.O1CCOCC1>[Cl-:23].[F:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[O:12][CH2:13][CH2:14][NH3+:15]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86709754HCID 86709754, compound

Product 1

HCID 68151396HCID 68151396, compoundYield 95%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
0 °C

Procedure

To a cooled (0° C.) single necked flask containing a solution of tert-butyl {2-[(1-fluoronaphthalen-2-yl)oxy]ethyl}carbamate in 5 mL of ethyl ether, 5 mL of 4 M HCl solution in dioxane were added. The resulting mixture was stirred at room temperature for 18 h. The reaction mixture was concentrated under reduce pressure to afford 2-[(1-fluoronaphthalen-2-yl)oxy]ethanaminium chloride as a white solid (95% yield) which was pure by TLC and NMR analysis.

Workup

  1. additionwere added
  2. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-eca7b5b7cf784964883089e8fdc6d479
Source dataset
uspto-grants-2014_12
Patent number
US08906946B2

Reaction notes

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