3-Chlorothiophene-2-carbaldehyde → 5-Chloro-6-(2-{[(5-chlorothiophen-2-yl)methyl]amino}ethoxy)naphthalene-2-carbonitrile

HRID 1400306Notes

Reaction equation

HRID 1400306 reaction equation
[Cl-:1].[Cl:2][C:3]1[C:12]2[C:7](=[CH:8][C:9]([C:13]#[N:14])=[CH:10][CH:11]=2)[CH:6]=[CH:5][C:4]=1[O:15][CH2:16][CH2:17][NH3+:18].Cl[C:20]1[CH:24]=[CH:23][S:22][C:21]=1[CH:25]=O>>[Cl:2][C:3]1[C:4]([O:15][CH2:16][CH2:17][NH:18][CH2:25][C:21]2[S:22][C:23]([Cl:1])=[CH:24][CH:20]=2)=[CH:5][CH:6]=[C:7]2[C:12]=1[CH:11]=[CH:10][C:9]([C:13]#[N:14])=[CH:8]2

Participants

3

Reactant 2

HCID 27358253-Chlorothiophene-2-carbaldehydeHCID 681512872-[(1-Chloro-6-cyanonaphthalen-2-yl)oxy]ethanaminium chloride

Product 1

HCID 590536645-Chloro-6-(2-{[(5-chlorothiophen-2-yl)methyl]amino}ethoxy)naphthalene-2-carbonitrileYield 63%

Procedure

Prepared from 2-[(1-chloro-6-cyanonaphthalen-2-yl)oxy]ethanaminium chloride and 5 chlorothiophen-2-carbaldehyde in 63% yield as a yellow solid.

Sources & evidence

ORD record
ord-b848fc7f11fc436182d6e87100212462
Source dataset
uspto-grants-2014_12
Patent number
US08906946B2

Reaction notes

Loading…