Hydroxylamine → HCID 45276554, compound

HRID 1400671Notes

Reaction equation

[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([CH2:9][N:10]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([C:19]([OH:21])=O)[CH:17]=3)[CH:12]=[CH:11]2)=[CH:5][CH:4]=1.[NH2:22][OH:23]>>[OH:23][NH:22][C:19]([C:16]1[CH:17]=[C:18]2[C:13]([CH:12]=[CH:11][N:10]2[CH2:9][C:6]2[CH:7]=[N:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)=[CH:14][CH:15]=1)=[O:21]

Participants

Reactant 2

HCID 787Hydroxylamine

HCID 58213836HCID 58213836, compound

Product 1

HCID 45276554HCID 45276554, compound

Procedure

1-((6-Methoxypyridin-3-yl)methyl)-1H-indole-6-carboxylic acid was activated and coupled with NH2OH as described in Example 4, Step 3 to provide N-hydroxy-1-((6-methoxypyridin-3-yl)methyl)-1H-indole-6-carboxamide as a tan solid.

Sources & evidence

ORD record: ord-fbe53ee91df94dfd8c255dab7dfecb4b
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08906954B2

Reaction notes

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