Hydroxylamine → HCID 86652336, compound

HRID 1400674Notes

Reaction equation

[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][C:8]2[CH:28]=[CH:27][C:11]([O:12][CH2:13][CH2:14][N:15]3[C:23]4[C:18](=[CH:19][CH:20]=[C:21]([C:24]([O-:26])=O)[CH:22]=4)[CH:17]=[CH:16]3)=[CH:10][CH:9]=2)[CH2:3][CH2:2]1.[NH2:29][OH:30]>>[O:1]1[CH2:2][CH2:3][N:4]([CH2:7][C:8]2[CH:9]=[CH:10][C:11]([O:12][CH2:13][CH2:14][N:15]3[C:23]4[C:18](=[CH:19][CH:20]=[C:21]([C:24]([NH:29][OH:30])=[O:26])[CH:22]=4)[CH:17]=[CH:16]3)=[CH:27][CH:28]=2)[CH2:5][CH2:6]1

Participants

Reactant 2

HCID 787Hydroxylamine

HCID 86652337HCID 86652337, compound

Product 1

HCID 86652336HCID 86652336, compound

Procedure

1-(2-(4-(morpholinomethyl)phenoxy)ethyl)-1H-indole-6-carboxylate was activated and coupled with NH2OH as described in Example 4, Step 3 to provide 1-(2-(4-(morpholinomethyl)phenoxy)ethyl)-N-hydroxy-1H-indole-6-carboxamide as a tan solid.

Sources & evidence

ORD record: ord-caff5ebf87f443db83b3aaaf65420955
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08906954B2

Reaction notes

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