HRID1400709

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C=CCCc1ccccc1-c1cccc(-c2cc3nc(C)c([C@H](OC(C)(C)C)C(=O)OC)c(-c4cc5c(cc4C)OCCN5CC=C)n3n2)c1

HCID86710760

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@@H](OC(C)(C)C)c1c(C)nc2cc3nn2c1-c1cc2c(cc1C)OCCN2CC=CCCc1ccccc1-c1cccc-3c1

HCID86710762

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

结构：Cc1cc(C)c(N2CCN(c3c(C)cc(C)cc3C)[C]2=[Ru]([Cl])([Cl])=[CH]c2ccccc2OC(C)C)c(C)c1

催化剂HCID11763533

[1,3-Bis(2,4,6-trimethylphenyl)imidazolidin-2-ylidene](dichloro)({2-[(propan-2-yl)oxy]phenyl}methylidene)ruthenium

C31H38Cl2N2ORu

溶剂HCID11

1,2-Dichloroethane

C2H4Cl2

PROCEDURE

实验过程

A solution of (2S)-methyl 2-(7-(4-allyl-7-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-2-(2′-(but-3-en-1-yl)-[1,1′-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate (0.030 g, 0.045 mmol) in dry DCE (5 mL) was heated (70° C. oil bath) and then treated with Hoveyda-Grubbs Cat. 2nd Gen. (3 mg, 5 μmol). The reaction was stirred for 90 min. The solvent was removed and the intermediate was used immediately in the following step. LCMS (M+H)=643.4.

WORKUP

后处理

customThe solvent was removed

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6731a6ff097247c4b59bb073ee723242
来源数据集: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08906929B2
来源说明: uspto-grants-2014_12

反应 SMILES

[CH2:1]([N:4]1[CH2:9][CH2:8][O:7][C:6]2[CH:10]=[C:11]([CH3:50])[C:12]([C:14]3[N:19]4[N:20]=[C:21]([C:23]5[CH:24]=[C:25]([C:29]6[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=6[CH2:35][CH2:36][CH:37]=[CH2:38])[CH:26]=[CH:27][CH:28]=5)[CH:22]=[C:18]4[N:17]=[C:16]([CH3:39])[C:15]=3[C@H:40]([O:45][C:46]([CH3:49])([CH3:48])[CH3:47])[C:41]([O:43][CH3:44])=[O:42])=[CH:13][C:5]1=2)C=C>ClCCCl.CC1C=C(C)C(N2C(=[Ru](Cl)(Cl)=CC3C(OC(C)C)=CC=CC=3)N(C3C(C)=CC(C)=CC=3C)CC2)=C(C)C=1>[C:46]([O:45][C@@H:40]([C:15]1[C:16]([CH3:39])=[N:17][C:18]2=[CH:22][C:21]3=[N:20][N:19]2[C:14]=1[C:12]1[CH:13]=[C:5]2[C:6]([O:7][CH2:8][CH2:9][N:4]2[CH2:1][CH:38]=[CH:37][CH2:36][CH2:35][C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][C:29]=2[C:25]2[CH:24]=[C:23]3[CH:28]=[CH:27][CH:26]=2)=[CH:10][C:11]=1[CH3:50])[C:41]([O:43][CH3:44])=[O:42])([CH3:49])([CH3:48])[CH3:47]