HRID1400710

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)[C@@H](OC(C)(C)C)c1c(C)nc2cc3nn2c1-c1cc2c(cc1C)OCCN2CC=CCCc1ccccc1-c1cccc-3c1

HCID86710762

未命名化合物

PRODUCTS

生成物

HCID86710761

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

A solution of methyl (2S)-2-(tert-butoxy)-2-[4,32-dimethyl-29-oxa-5,7,8,26-tetraazaheptacyclo[24.6.2.16,9.110,14.02,7.015,20.030,34]hexatriaconta-1 (32),2,4,6(36),8,10(35), 11,13,15 (20),16,18,23,30,33-tetradecaen-3-yl]acetate in MeOH (4 mL), was treated with 10 wt % Pd/C (5 mg, 0.05 mmol), evacuated and hydrogen purged three times, then stirred under hydrogen atmosphere for 18 h. The reaction was filtered (0.45 μm syringe tip filter), concentrated to a film, and the residue was used immediately in the following step. LCMS (M+H)=645.4.

WORKUP

后处理

customevacuated
customhydrogen purged three times
filtrationThe reaction was filtered
filtration(0.45 μm syringe tip filter)
concentrationconcentrated to a film

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-955303a095db4762a08709d2d4234a71
来源数据集: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08906929B2
来源说明: uspto-grants-2014_12

反应 SMILES

[C:1]([O:5][C@@H:6]([C:11]1[C:42]([CH3:43])=[N:41][C:40]2=[CH:44][C:37]3=[N:38][N:39]2[C:12]=1[C:13]1[CH:47]=[C:46]2[C:16]([O:17][CH2:18][CH2:19][N:20]2[CH2:21][CH:22]=[CH:23][CH2:24][CH2:25][C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][C:31]=2[C:32]2[CH:45]=[C:36]3[CH:35]=[CH:34][CH:33]=2)=[CH:15][C:14]=1[CH3:48])[C:7]([O:9][CH3:10])=[O:8])([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[C:1]([O:5][C@@H:6]([C:11]1[C:42]([CH3:43])=[N:41][C:40]2=[CH:44][C:37]3=[N:38][N:39]2[C:12]=1[C:13]1[CH:47]=[C:46]2[C:16]([O:17][CH2:18][CH2:19][N:20]2[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][C:31]=2[C:32]2[CH:45]=[C:36]3[CH:35]=[CH:34][CH:33]=2)=[CH:15][C:14]=1[CH3:48])[C:7]([O:9][CH3:10])=[O:8])([CH3:4])([CH3:3])[CH3:2]