methyl (2S)-2-(4,32-dimethyl-29-oxa-5,7,8,26-tetrazaheptacyclo[24.6.2.16,9.110,14.02,7.015,20.030,34]hexatriaconta-1(33),2,4,6(36),8,10,12,14(35),15,17,19,23,30(34),31-tetradecaen-3-yl)-2-[(2-methylpropan-2-yl)oxy]acetate → methyl (2S)-2-(4,32-dimethyl-29-oxa-5,7,8,26-tetrazaheptacyclo[24.6.2.16,9.110,14.02,7.015,20.030,34]hexatriaconta-1(33),2,4,6(36),8,10,12,14(35),15,17,19,30(34),31-tridecaen-3-yl)-2-[(2-methylpropan-2-yl)oxy]acetate

Participants

Reaction Steps

A solution of methyl (2S)-2-(tert-butoxy)-2-[4,32-dimethyl-29-oxa-5,7,8,26-tetraazaheptacyclo[24.6.2.16,9.110,14.02,7.015,20.030,34]hexatriaconta-1 (32),2,4,6(36),8,10(35), 11,13,15 (20),16,18,23,30,33-tetradecaen-3-yl]acetate in MeOH (4 mL), was treated with 10 wt % Pd/C (5 mg, 0.05 mmol), evacuated and hydrogen purged three times, then stirred under hydrogen atmosphere for 18 h. The reaction was filtered (0.45 μm syringe tip filter), concentrated to a film, and the residue was used immediately in the following step. LCMS (M+H)=645.4.

Provenance & Evidence