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HRID14009

反应详情

EQUATION

反应方程式

HRID 14009 的结构方程式

REACTANTS

反应物

3
结构：[Cl-].[NH4+]
HCID25517

未命名化合物

结构：[N-]=[N+]=[N-].[Na+]
HCID33557

未命名化合物

结构：CC(C)(C)OC(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H]1CO1
HCID9922319

tert-Butyl {(1S)-2-(3,5-difluorophenyl)-1-[(2S)-oxiran-2-yl]ethyl}carbamate

C15H19F2NO3

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CN=[N+]=[N-]
HCID131726251

未命名化合物

CONDITIONS

反应条件

温度
77.5 °C

PROCEDURE

实验过程

Sodium azide (0.22 g, 4 mmole) and ammonium chloride (2 eq) are added to tert-butyl (1S)-2-(3,5-difluorophenyl)-1-[(2S)-oxiranyl]ethylcarbamate (V, EXAMPLE 3, 0.6 g, 2 mmole). The reaction is heated to 75-80 degrees C. and stirred for 16 hours. The reaction is monitored by TLC to insure completion. The solvent is removed under reduced pressure. The concentrate is partitioned between ethyl acetate and water, the phases are separated and the organic phase is washed with bicarbonate and saline, dried over anhydrous sodium sulfate and concentrated to give the title compound, TLC (ethyl acetate/hexane) Rf=0.45; MS (MH+)=343.

WORKUP

后处理

  1. customThe solvent is removed under reduced pressure
  2. customThe concentrate is partitioned between ethyl acetate and water
  3. customthe phases are separated
  4. washthe organic phase is washed with bicarbonate and saline
  5. dry with materialdried over anhydrous sodium sulfate
  6. concentrationconcentrated