HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Carbethoxy-3-methyl-2-cyclohexen-1-one → Ethyl 2-methyl-4-(((trifluoromethyl)sulfonyl)oxy)cyclohexa-2,4-dienecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Carbethoxy-3-methyl-2-cyclohexen-1-one | HCID 79020 | — |
| Reactant | (1R,3aS,5aR,5bR,7aR,11aR,11bR,13aR,13bR)-3a-((2-(1,1-dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl trifluoromethanesulfonate | HCID 71698666 | — |
| Product | Ethyl 2-methyl-4-(((trifluoromethyl)sulfonyl)oxy)cyclohexa-2,4-dienecarboxylate | HCID 86692379 | 62.7% |
Reaction Steps
The title compound was prepared following the procedure described in Method 2 for the preparation of Intermediate 1, Step 6, using ethyl 2-methyl-4-oxocyclohex-2-enecarboxylate as the reactant. (62.7% yield). 1H NMR (400 MHz, CHLOROFORM-d) δ 5.93 (t, J=1.3 Hz, 1H), 4.30-4.09 (m, 2H), 2.83-2.68 (m, 2H), 2.62-2.43 (m, 2H), 2.18 (t, J=1.9 Hz, 3H), 1.37-1.20 (m, 3H). 19F NMR (376 MHz, CHLOROFORM-d) δ −73.63 (s, 3F).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08906889B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-0785a66d21d94f44920e4c958a9ef18e |
| Source note | uspto-grants-2014_12 |