Trifluoroacetic acid → {4-[6-(2-Fluorophenoxy)oxazolo[4,5-c]pyridin-2-yl]-2,6-dimethylphenoxy}acetic acid

HRID 1401114Notes

Reaction equation

HRID 1401114 reaction equation
FC(F)(F)C(O)=O.[F:8][C:9]1[CH:41]=[CH:40][CH:39]=[CH:38][C:10]=1[O:11][C:12]1[N:17]=[CH:16][C:15]2[N:18]=[C:19]([C:21]3[CH:35]=[C:34]([CH3:36])[C:24]([O:25][CH2:26][C:27]([O:29]C(C)(C)C)=[O:28])=[C:23]([CH3:37])[CH:22]=3)[O:20][C:14]=2[CH:13]=1>ClCCl>[F:8][C:9]1[CH:41]=[CH:40][CH:39]=[CH:38][C:10]=1[O:11][C:12]1[N:17]=[CH:16][C:15]2[N:18]=[C:19]([C:21]3[CH:22]=[C:23]([CH3:37])[C:24]([O:25][CH2:26][C:27]([OH:29])=[O:28])=[C:34]([CH3:36])[CH:35]=3)[O:20][C:14]=2[CH:13]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 71186150tert-Butyl {4-[6-(2-fluorophenoxy)oxazolo[4,5-c]pyridin-2-yl]-2,6-dimethylphenoxy}acetate

Product 1

HCID 71186241{4-[6-(2-Fluorophenoxy)oxazolo[4,5-c]pyridin-2-yl]-2,6-dimethylphenoxy}acetic acid

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

0.8 ml of trifluoroacetic acid was added to a solution of 90 mg of tert-butyl {4-[6-(2-fluorophenoxy)oxazolo[4,5-c]pyridin-2-yl]-2,6-dimethylphenoxy}acetate in 2 ml of dichloromethane, and the mixture was stirred at room temperature for 2 h. The reaction was then concentrated under reduced pressure and freeze-dried. This gave 101 mg (100%) of the title compound.

Workup

  1. concentrationThe reaction was then concentrated under reduced pressure
  2. customfreeze-dried

Sources & evidence

ORD record
ord-888348b38f504bad93b1a8e33de5a36c
Source dataset
uspto-grants-2014_12
Patent number
US08907093B2

Reaction notes

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