Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Reactant | 4-(2,2-Dibromovinyl)-2-fluoro-1-methoxybenzene | HCID 59455077 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 59455074 | HCID 59455074 | 81.4% |
Reaction Steps
A mixture of 1-(2,2-dibromo-vinyl)-3-fluoro-4-methoxybenzene (0.5 g, 0.00161 mol), potassium tertbutoxide (0.36 g, 0.00322 mol) and toluene (6 mL) were heated at 80° C. for 4 h. After completion, the reaction mixture was cooled to RT, diluted with water (15 mL), and extracted with EtOAc (3×50 mL). The organic layer was dried over anhydrous sodium sulfate and concentrated under reduce pressure to obtain product as a yellow oil (0.3 g, 81%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08907097B2 |
|---|
| Source dataset | uspto-grants-2014_12 |
|---|
| ORD ID | ord-cea7bcb63f7a4d42b0f2621ee32dd939 |
|---|
| Source note | uspto-grants-2014_12 |
|---|
