反应详情

The preparation is carried out starting from 1-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidin-4-ylamine hydrobromide and (R)-2,2-dimethyl-1,3-dioxolane-4-carbaldehyde. The protecting group is cleaved off as described by means of a 1.25 N HCl/methanol solution. The product was converted into the hydrochloride.