HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → HCID 67323237, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-Butanol, 4-bromo-, 1-acetate | HCID 78491 | — |
| Reactant | HCID 68381095 | HCID 68381095 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 67323237 | HCID 67323237 | — |
Reaction Steps
The preparation was carried out as already described starting from 120 mg (0.19 mmol) of 1-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidin-4-ylamine hydrochloride (preparation described above) and 57 μl (0.38 mmol) of 4-bromobutyl acetate. The protecting group was cleaved off by means of a 1N NaOH solution in methanol. The product was purified by means of preparative HPLC and is in the form of the hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08907098B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-065a7282b8ab451e99475c9ae474e0b4 |
| Source note | uspto-grants-2014_12 |