(6-Bromohexyloxy)-tert-butyldimethylsilane → HCID 67322787, compound

HRID 1401779Notes

Reaction equation

HRID 1401779 reaction equation
Cl.[CH3:2][C:3]1([CH3:26])[CH2:12][CH2:11][C:10]([CH3:14])([CH3:13])[C:9]2[CH:8]=[C:7]([C:15]3[N:16]=[C:17]([CH:20]4[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]4)[S:18][CH:19]=3)[CH:6]=[CH:5][C:4]1=2.Br[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][O:34][Si](C(C)(C)C)(C)C>>[CH3:2][C:3]1([CH3:26])[CH2:12][CH2:11][C:10]([CH3:13])([CH3:14])[C:9]2[CH:8]=[C:7]([C:15]3[N:16]=[C:17]([CH:20]4[CH2:25][CH2:24][N:23]([CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][OH:34])[CH2:22][CH2:21]4)[S:18][CH:19]=3)[CH:6]=[CH:5][C:4]1=2

Participants

3

Reactant 2

HCID 4260352(6-Bromohexyloxy)-tert-butyldimethylsilaneHCID 67166643HCID 67166643, compound

Product 1

HCID 67322787HCID 67322787, compound

Procedure

The preparation was carried out as already described starting from 100 mg (0.26 mmol) of 4-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidine hydrochloride and 92 mg (0.31 mmol) of (6-bromohexyloxy)-tert-butyldimethylsilane. The product was purified by means of flash chromatography on silica gel. The protecting group was cleaved off as already described using an HCl solution in dioxane. The product is in the form of the hydrochloride.

Workup

  1. customThe product was purified by means of flash chromatography on silica gel

Sources & evidence

ORD record
ord-74a2796b033e4d2e822dcb9e524ab0f3
Source dataset
uspto-grants-2014_12
Patent number
US08907098B2

Reaction notes

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