(6-Bromohexyloxy)-tert-butyldimethylsilane → HCID 67322787, compound

Participants

Reaction Steps

The preparation was carried out as already described starting from 100 mg (0.26 mmol) of 4-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidine hydrochloride and 92 mg (0.31 mmol) of (6-bromohexyloxy)-tert-butyldimethylsilane. The product was purified by means of flash chromatography on silica gel. The protecting group was cleaved off as already described using an HCl solution in dioxane. The product is in the form of the hydrochloride.

Provenance & Evidence