HRID1401784

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：CC(C)(C)OC(=O)N1CC[C@H](O)[C@H]1C(=O)O

HCID14037017

(3S)-1-(tert-Butoxycarbonyl)-3-hydroxy-L-proline

C10H17NO5

结构：CC1(C)CCC(C)(C)c2cc(-c3csc(N4CCC(N)CC4)n3)ccc21

HCID53312200

未命名化合物

PRODUCTS

生成物

结构：CC1(C)CCC(C)(C)c2cc(-c3csc(N4CCC(NC(=O)[C@H]5NCC[C@@H]5O)CC4)n3)ccc21

HCID67324366

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

The preparation was carried out analogously starting from 244 mg (0.50 mmol) of 1-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidin-4-ylamine and 116 mg (0.50 mmol) of (2S,3S)-3-hydroxypyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester. The protecting group was cleaved off analogously using HCl in dioxane. The product was purified by means of flash chromatography on silica gel.

WORKUP

后处理

customThe product was purified by means of flash chromatography on silica gel