Hydrochloric Acid → HCID 67324366, compound

HRID 1401784Notes

Reaction equation

HRID 1401784 reaction equation
[CH3:1][C:2]1([CH3:26])[CH2:11][CH2:10][C:9]([CH3:13])([CH3:12])[C:8]2[CH:7]=[C:6]([C:14]3[N:15]=[C:16]([N:19]4[CH2:24][CH2:23][CH:22]([NH2:25])[CH2:21][CH2:20]4)[S:17][CH:18]=3)[CH:5]=[CH:4][C:3]1=2.C(OC([N:34]1[CH2:38][CH2:37][C@H:36]([OH:39])[C@H:35]1[C:40](O)=[O:41])=O)(C)(C)C.Cl>O1CCOCC1>[CH3:1][C:2]1([CH3:26])[CH2:11][CH2:10][C:9]([CH3:12])([CH3:13])[C:8]2[CH:7]=[C:6]([C:14]3[N:15]=[C:16]([N:19]4[CH2:24][CH2:23][CH:22]([NH:25][C:40]([C@@H:35]5[C@@H:36]([OH:39])[CH2:37][CH2:38][NH:34]5)=[O:41])[CH2:21][CH2:20]4)[S:17][CH:18]=3)[CH:5]=[CH:4][C:3]1=2

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14037017(2S,3S)-1-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine-2-carboxylic acidHCID 53312200HCID 53312200, compound

Product 1

HCID 67324366HCID 67324366, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The preparation was carried out analogously starting from 244 mg (0.50 mmol) of 1-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidin-4-ylamine and 116 mg (0.50 mmol) of (2S,3S)-3-hydroxypyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester. The protecting group was cleaved off analogously using HCl in dioxane. The product was purified by means of flash chromatography on silica gel.

Workup

  1. customThe product was purified by means of flash chromatography on silica gel

Sources & evidence

ORD record
ord-ddc62276da474bd4bbad61cf84768d28
Source dataset
uspto-grants-2014_12
Patent number
US08907098B2

Reaction notes

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