Trifluoroacetic acid → HCID 53311625, compound

HRID 1401800Notes

Reaction equation

HRID 1401800 reaction equation
Br.[CH3:2][C:3]1([CH3:26])[CH2:12][CH2:11][C:10]([CH3:14])([CH3:13])[C:9]2[CH:8]=[C:7]([C:15]3[N:16]=[C:17]([N:20]4[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]4)[S:18][CH:19]=3)[CH:6]=[CH:5][C:4]1=2.C([O:29][C:30](=[O:35])[CH2:31][CH2:32][CH2:33]Br)C.C(O)(C(F)(F)F)=O>>[CH3:2][C:3]1([CH3:26])[CH2:12][CH2:11][C:10]([CH3:13])([CH3:14])[C:9]2[CH:8]=[C:7]([C:15]3[N:16]=[C:17]([N:20]4[CH2:21][CH2:22][N:23]([CH2:33][CH2:32][CH2:31][C:30]([OH:35])=[O:29])[CH2:24][CH2:25]4)[S:18][CH:19]=3)[CH:6]=[CH:5][C:4]1=2

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 76300Ethyl 4-bromobutyrateHCID 68380514HCID 68380514, compound

Product 1

HCID 53311625HCID 53311625, compound

Procedure

The preparation was carried out analogously starting from 100 mg (0.17 mmol) of 1-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperazine hydrobromide and 63 mg (0.35 mmol) of 4-bromobutyric acid ethyl ester. The product is in the form of the TFA salt.

Sources & evidence

ORD record
ord-156babf72c98494c8dfd0e98c25cff2d
Source dataset
uspto-grants-2014_12
Patent number
US08907098B2

Reaction notes

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