5-Hydroxypentanal → HCID 67323291, compound

HRID 1401810Notes

Reaction equation

HRID 1401810 reaction equation
[CH3:1][C:2]1([CH3:25])[CH2:11][CH2:10][C:9]([CH3:13])([CH3:12])[C:8]2[CH:7]=[C:6]([C:14]3[CH:18]=[C:17]([N:19]4[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]4)[O:16][N:15]=3)[CH:5]=[CH:4][C:3]1=2.[OH:26][CH2:27][CH2:28][CH2:29][CH2:30][CH:31]=O>>[CH3:1][C:2]1([CH3:25])[CH2:11][CH2:10][C:9]([CH3:12])([CH3:13])[C:8]2[CH:7]=[C:6]([C:14]3[CH:18]=[C:17]([N:19]4[CH2:20][CH2:21][N:22]([CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][OH:26])[CH2:23][CH2:24]4)[O:16][N:15]=3)[CH:5]=[CH:4][C:3]1=2

Participants

3

Reactant 2

HCID 202055-HydroxypentanalHCID 67325216HCID 67325216, compound

Product 1

HCID 67323291HCID 67323291, compound

Procedure

The preparation was carried out as already described via a reductive amination starting from 26 mg (0.05 mmol) of 1-[3-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)isoxazol-5-yl]piperazine and 5 mg (0.05 mmol) of 5-hydroxypentanal. The product was purified by means of preparative HPLC and converted into the hydrochloride by treatment with methanolic HCl.

Workup

  1. customThe product was purified by means of preparative HPLC

Sources & evidence

ORD record
ord-2b7a054b2b3f4053a1452b12fc2191a3
Source dataset
uspto-grants-2014_12
Patent number
US08907098B2

Reaction notes

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