HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → HCID 53311710, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-Butanol, 4-bromo-, 1-acetate | HCID 78491 | — |
| Reactant | HCID 53311789 | HCID 53311789 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 53311710 | HCID 53311710 | — |
Reaction Steps
The preparation was carried out as already described starting from 125 mg (0.35 mmol) of 4-[5-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-thiadiazol-2-yl]piperidine and 76 μl (0.53 mmol) of 4-bromobutyl acetate. The protecting group was cleaved off by means of a 1N NaOH solution in methanol. The product was purified by means of preparative HPLC and converted into the hydrochloride by treatment with methanolic HCl.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08907098B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-74395fd359dc421abd9c8cb292647de6 |
| Source note | uspto-grants-2014_12 |