Hydrogen Bromide → HCID 58246458, compound

HRID 1401825Notes

Reaction equation

HRID 1401825 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:14]=[CH:13][C:12]2[CH:11]([CH3:15])[CH2:10][CH2:9][CH:8]([CH3:16])[C:7]=2[CH:6]=1)=O.C(OC([N:24]1[CH2:29][CH2:28][CH:27]([C:30](=[S:32])[NH2:31])[CH2:26][CH2:25]1)=O)(C)(C)C.Br>>[CH3:15][CH:11]1[CH2:10][CH2:9][CH:8]([CH3:16])[C:7]2[CH:6]=[C:5]([C:3]3[N:31]=[C:30]([CH:27]4[CH2:28][CH2:29][NH:24][CH2:25][CH2:26]4)[S:32][CH:2]=3)[CH:14]=[CH:13][C:12]1=2

Participants

4

Reactant 3

HCID 260Hydrogen BromideHCID 2735648tert-Butyl 4-carbamothioylpiperidine-1-carboxylateHCID 53312114HCID 53312114, compound

Product 1

HCID 58246458HCID 58246458, compound

Procedure

The preparation was carried out as already described starting from 1.09 g (2.05 mmol) of 2-bromo-1-(5,8-dimethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethanone and 500 mg (2.05 mmol) of 4-thiocarbamoylpiperidine-1-carboxylic acid tert-butyl ester. The product is in the form of the hydrobromide.

Sources & evidence

ORD record
ord-2cac720ef76247a49ed685138ac2e7a5
Source dataset
uspto-grants-2014_12
Patent number
US08907098B2

Reaction notes

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