Hydrochloric Acid → HCID 67324274, compound

HRID 1401827Notes

Reaction equation

HRID 1401827 reaction equation
Br.[CH3:2][CH:3]1[CH2:12][CH2:11][CH:10]([CH3:13])[C:9]2[CH:8]=[C:7]([C:14]3[N:15]=[C:16]([CH:19]4[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]4)[S:17][CH:18]=3)[CH:6]=[CH:5][C:4]1=2.[OH:25][CH2:26][CH2:27][CH2:28][CH2:29][CH:30]=O.Cl>>[CH3:2][CH:3]1[CH2:12][CH2:11][CH:10]([CH3:13])[C:9]2[CH:8]=[C:7]([C:14]3[N:15]=[C:16]([CH:19]4[CH2:24][CH2:23][N:22]([CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][OH:25])[CH2:21][CH2:20]4)[S:17][CH:18]=3)[CH:6]=[CH:5][C:4]1=2

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 202055-HydroxypentanalHCID 68380594HCID 68380594, compound

Product 1

HCID 67324274HCID 67324274, compound

Procedure

The preparation was carried out as already described via a reductive amination starting from 100 mg (0.25 mmol) of 4-[4-(5,8-dimethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidine hydrobromide and 50 mg (0.49 mmol) of 5-hydroxypentanal. The product is in the form of the hydrochloride.

Sources & evidence

ORD record
ord-98e9edf460cb4a998f0b984975e43009
Source dataset
uspto-grants-2014_12
Patent number
US08907098B2

Reaction notes

Loading…