Sodium Hydroxide → HCID 67322961, compound

HRID 1401832Notes

Reaction equation

HRID 1401832 reaction equation
Cl.[CH3:2][C:3]1([CH3:26])[CH2:12][CH2:11][C:10]([CH3:14])([CH3:13])[C:9]2[CH:8]=[C:7]([C:15]3[N:16]=[N:17][N:18]([CH:20]4[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]4)[CH:19]=3)[CH:6]=[CH:5][C:4]1=2.Cl[CH2:28][CH2:29][CH2:30][CH2:31][O:32]C(=O)C.[OH-].[Na+]>CO>[CH3:2][C:3]1([CH3:26])[CH2:12][CH2:11][C:10]([CH3:13])([CH3:14])[C:9]2[CH:8]=[C:7]([C:15]3[N:16]=[N:17][N:18]([CH:20]4[CH2:25][CH2:24][N:23]([CH2:28][CH2:29][CH2:30][CH2:31][OH:32])[CH2:22][CH2:21]4)[CH:19]=3)[CH:6]=[CH:5][C:4]1=2

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 233991-Butanol, 4-chloro-, 1-acetateHCID 68380921HCID 68380921, compound

Product 1

HCID 67322961HCID 67322961, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The preparation was carried out as already described starting from 24 mg (0.06 mmol) of 4-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,2,3-triazol-1-yl]piperidine hydrochloride and 13 μl (0.11 mmol) of acetic acid 4-chlorobutyl ester. The protecting group was cleaved off by means of a 1N sodium hydroxide solution in methanol. The product was purified by means of preparative HPLC and is in the form of the hydrochloride.

Workup

  1. customThe product was purified by means of preparative HPLC

Sources & evidence

ORD record
ord-1bbbe569436a42b281acb7abdb5ba809
Source dataset
uspto-grants-2014_12
Patent number
US08907098B2

Reaction notes

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