HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → HCID 67322961, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-Butanol, 4-chloro-, 1-acetate | HCID 23399 | — |
| Reactant | HCID 68380921 | HCID 68380921 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 67322961 | HCID 67322961 | — |
Reaction Steps
The preparation was carried out as already described starting from 24 mg (0.06 mmol) of 4-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,2,3-triazol-1-yl]piperidine hydrochloride and 13 μl (0.11 mmol) of acetic acid 4-chlorobutyl ester. The protecting group was cleaved off by means of a 1N sodium hydroxide solution in methanol. The product was purified by means of preparative HPLC and is in the form of the hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08907098B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-1bbbe569436a42b281acb7abdb5ba809 |
| Source note | uspto-grants-2014_12 |