Hydrochloric Acid → HCID 53311540, compound

HRID 1401836Notes

Reaction equation

HRID 1401836 reaction equation
[CH3:1][CH:2]1[CH2:11][CH2:10][CH:9]([CH3:12])[C:8]2[CH:7]=[C:6]([C:13]3[N:14]=[C:15]([N:18]4[CH2:23][CH2:22][CH:21]([NH2:24])[CH2:20][CH2:19]4)[S:16][CH:17]=3)[CH:5]=[CH:4][C:3]1=2.C([O:28][CH2:29][CH2:30][CH2:31][CH2:32]Br)(=O)C.[OH-].[Na+].Cl>CO>[CH3:1][CH:2]1[CH2:11][CH2:10][CH:9]([CH3:12])[C:8]2[CH:7]=[C:6]([C:13]3[N:14]=[C:15]([N:18]4[CH2:23][CH2:22][CH:21]([NH:24][CH2:32][CH2:31][CH2:30][CH2:29][OH:28])[CH2:20][CH2:19]4)[S:16][CH:17]=3)[CH:5]=[CH:4][C:3]1=2

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 784911-Butanol, 4-bromo-, 1-acetateHCID 53312288HCID 53312288, compound

Product 1

HCID 53311540HCID 53311540, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The preparation is carried out as described starting from 218 mg (0.58 mmol) of 1-[4-(5,8-dimethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidin-4-ylamine and 126 μl (0.58 mmol) of 4-bromobutyl acetate. The protecting group is cleaved off by means of a 1N NaOH solution in methanol. The product is in the form of the hydrochloride.

Sources & evidence

ORD record
ord-d465bf2582d6409fbeff0a5da42eb23c
Source dataset
uspto-grants-2014_12
Patent number
US08907098B2

Reaction notes

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