tert-Butyl 4-carbamothioylpiperidine-1-carboxylate → 4-[4-(5,6,7,8-Tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidine

HRID 1401839Notes

Reaction equation

HRID 1401839 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:14]=[CH:13][C:12]2[CH2:11][CH2:10][CH2:9][CH2:8][C:7]=2[CH:6]=1)=O.C(OC([N:22]1[CH2:27][CH2:26][CH:25]([C:28](=[S:30])[NH2:29])[CH2:24][CH2:23]1)=O)(C)(C)C>>[CH:6]1[C:7]2[CH2:8][CH2:9][CH2:10][CH2:11][C:12]=2[CH:13]=[CH:14][C:5]=1[C:3]1[N:29]=[C:28]([CH:25]2[CH2:26][CH2:27][NH:22][CH2:23][CH2:24]2)[S:30][CH:2]=1

Participants

3

Reactant 2

HCID 2735648tert-Butyl 4-carbamothioylpiperidine-1-carboxylateHCID 73539912-Bromo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)ethan-1-one

Product 1

HCID 242618404-[4-(5,6,7,8-Tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidine

Procedure

The preparation is carried out as described starting from 8 g (31.6 mmol) of 2-bromo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)ethanone and 8 g (32.7 mmol) of 4-thiocarbamoylpiperidine-1-carboxylic acid tert-butyl ester.

Sources & evidence

ORD record
ord-831d6025d35f4f298387c5ad117f0836
Source dataset
uspto-grants-2014_12
Patent number
US08907098B2

Reaction notes

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