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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1401839Generated: October 29, 2026

tert-Butyl 4-carbamothioylpiperidine-1-carboxylate → 4-[4-(5,6,7,8-Tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidine

https://huagongshe.com/reaction/1401839

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butyl 4-carbamothioylpiperidine-1-carboxylateHCID 2735648—
Reactant2-Bromo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)ethan-1-oneHCID 7353991—
Product4-[4-(5,6,7,8-Tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidineHCID 24261840—

Reaction Steps

The preparation is carried out as described starting from 8 g (31.6 mmol) of 2-bromo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)ethanone and 8 g (32.7 mmol) of 4-thiocarbamoylpiperidine-1-carboxylic acid tert-butyl ester.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08907098B2
Source datasetuspto-grants-2014_12
ORD IDord-831d6025d35f4f298387c5ad117f0836
Source noteuspto-grants-2014_12