HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-{4-[4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]-1,4-diazepan-1-yl}butan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-Butanol, 4-bromo-, 1-acetate | HCID 78491 | — |
| Reactant | 1-[4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]-1,4-diazepane | HCID 53311543 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-{4-[4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]-1,4-diazepan-1-yl}butan-1-ol | HCID 67323438 | — |
Reaction Steps
The preparation is carried out as already described starting from 79 mg (0.214 mmol) of 1-[4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]-1,4-diazepane and 47 μl (0.321 mmol) of 4-bromobutyl acetate. The protecting group is cleaved off by means of a 1N NaOH solution in methanol. The product is in the form of the hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08907098B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-68c66e2829af4e79aa98fdcd2ea0cf4c |
| Source note | uspto-grants-2014_12 |