Hydrochloric Acid → HCID 67325361, compound

HRID 1401847Notes

Reaction equation

HRID 1401847 reaction equation
[CH3:1][C:2]1([CH3:26])[CH2:11][CH2:10][C:9]([CH3:13])([CH3:12])[C:8]2[CH:7]=[C:6]([C:14]3[N:15]=[C:16]([N:19]4[CH2:24][CH2:23][CH2:22][CH:21]([NH2:25])[CH2:20]4)[S:17][CH:18]=3)[CH:5]=[CH:4][C:3]1=2.C([O:30][CH2:31][CH2:32][CH2:33][CH2:34]Br)(=O)C.[OH-].[Na+].Cl>CO>[CH3:1][C:2]1([CH3:26])[CH2:11][CH2:10][C:9]([CH3:12])([CH3:13])[C:8]2[CH:7]=[C:6]([C:14]3[N:15]=[C:16]([N:19]4[CH2:24][CH2:23][CH2:22][CH:21]([NH:25][CH2:34][CH2:33][CH2:32][CH2:31][OH:30])[CH2:20]4)[S:17][CH:18]=3)[CH:5]=[CH:4][C:3]1=2

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 784911-Butanol, 4-bromo-, 1-acetateHCID 53311542HCID 53311542, compound

Product 1

HCID 67325361HCID 67325361, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The preparation is carried out as described starting from 75 mg (0.20 mmol) of 1-[4(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidin-3-ylamine and 45 μl (0.31 mmol) of 4-bromobutyl acetate. The protecting group is cleaved off by means of a 1N NaOH solution in methanol. The product is in the form of the hydrochloride.

Sources & evidence

ORD record
ord-15d9ae0116df49ca971cc2fca4c656a3
Source dataset
uspto-grants-2014_12
Patent number
US08907098B2

Reaction notes

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