Hydrochloric Acid → HCID 67323897, compound

HRID 1401848Notes

Reaction equation

HRID 1401848 reaction equation
[CH3:1][C:2]1([CH3:26])[CH2:11][CH2:10][C:9]([CH3:13])([CH3:12])[C:8]2[CH:7]=[C:6]([C:14]3[N:15]=[C:16]([N:19]4[CH2:24][CH2:23][CH2:22][CH:21]([NH2:25])[CH2:20]4)[S:17][CH:18]=3)[CH:5]=[CH:4][C:3]1=2.Cl[CH2:28][CH2:29][CH2:30][OH:31].Cl>>[CH3:1][C:2]1([CH3:26])[CH2:11][CH2:10][C:9]([CH3:12])([CH3:13])[C:8]2[CH:7]=[C:6]([C:14]3[N:15]=[C:16]([N:19]4[CH2:24][CH2:23][CH2:22][CH:21]([NH:25][CH2:28][CH2:29][CH2:30][OH:31])[CH2:20]4)[S:17][CH:18]=3)[CH:5]=[CH:4][C:3]1=2

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 123133-Chloro-1-propanolHCID 53311542HCID 53311542, compound

Product 1

HCID 67323897HCID 67323897, compound

Procedure

The preparation is carried out as described starting from 50 mg (0.11 mmol) of 1-[4(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidin-3-ylamine and 14 μl (0.16 mmol) of 3-chloropropan-1-ol. The product is in the form of the hydrochloride.

Sources & evidence

ORD record
ord-66e40623818d4897aed418c3b22804e2
Source dataset
uspto-grants-2014_12
Patent number
US08907098B2

Reaction notes

Loading…