Formate → 2-{1-[4-(1,1,3,3-Tetramethylindan-5-yl)thiazol-2-yl]-piperidin-4-ylamino}ethanol

HRID 1401854Notes

Reaction equation

HRID 1401854 reaction equation
Br[C:2]1[N:3]=[C:4]([N:7]2[CH2:12][CH2:11][CH:10]([NH:13][CH2:14][CH2:15][OH:16])[CH2:9][CH2:8]2)[S:5][CH:6]=1.CC1(C)C(C)(C)OB([C:25]2[CH:26]=[C:27]3[C:31](=[CH:32][CH:33]=2)[C:30]([CH3:35])([CH3:34])[CH2:29][C:28]3([CH3:37])[CH3:36])O1.C([O-])=O>>[CH3:36][C:28]1([CH3:37])[C:27]2[C:31](=[CH:32][C:33]([C:2]3[N:3]=[C:4]([N:7]4[CH2:12][CH2:11][CH:10]([NH:13][CH2:14][CH2:15][OH:16])[CH2:9][CH2:8]4)[S:5][CH:6]=3)=[CH:25][CH:26]=2)[C:30]([CH3:35])([CH3:34])[CH2:29]1

Participants

4

Reactant 3

HCID 283FormateHCID 532501134,4,5,5-tetramethyl-2-(1,1,3,3-tetramethyl-2,3-dihydro-1H-inden-5-yl)-1,3,2-dioxaborolaneHCID 673233402-(1-(4-Bromothiazol-2-yl)piperidin-4-ylamino)ethanol

Product 1

HCID 673244632-{1-[4-(1,1,3,3-Tetramethylindan-5-yl)thiazol-2-yl]-piperidin-4-ylamino}ethanol

Procedure

The preparation is carried out as described above starting from 110 mg (0.29 mmol) of 2-[1-(4-bromothiazol-2-yl)piperidin-4-ylamino]ethanol and 98 mg (0.29 mmol) of 4,4,5,5-tetramethyl-2-(1,1,3,3-tetramethylindan-5-yl)-1,3,2-dioxaborolane. The product is in the form of the formate.

Sources & evidence

ORD record
ord-057923e65b5148caa795dd9d19861c5e
Source dataset
uspto-grants-2014_12
Patent number
US08907098B2

Reaction notes

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