Hydrochloric Acid → 2-{1-[4-(8,8-Dimethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidin-4-ylamino}ethanol

Participants

Role	Name	HCID	Charge
Reactant	Hydrochloric Acid	HCID 313	—
Reactant	2-(8,8-Dimethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane	HCID 53250114	—
Reactant	2-(1-(4-Bromothiazol-2-yl)piperidin-4-ylamino)ethanol	HCID 67323340	—
Product	2-{1-[4-(8,8-Dimethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidin-4-ylamino}ethanol	HCID 67323821	—

Reaction Steps

The preparation is carried out as described above starting from 100 mg (0.27 mmol) of 2-[1-(4-bromothiazol-2-yl)piperidin-4-ylamino]ethanol and 98 mg (0.30 mmol) of 2-(8,8-dimethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane. The product is in the form of the hydrochloride.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08907098B2
Source dataset	uspto-grants-2014_12
ORD ID	ord-0854d889772b42f7b0b2f67ffc2a76a0
Source note	uspto-grants-2014_12