Hydrochloric Acid → 2-{1-[4-(8,8-Dimethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidin-4-ylamino}ethanol

HRID 1401855Notes

Reaction equation

HRID 1401855 reaction equation
Br[C:2]1[N:3]=[C:4]([N:7]2[CH2:12][CH2:11][CH:10]([NH:13][CH2:14][CH2:15][OH:16])[CH2:9][CH2:8]2)[S:5][CH:6]=1.[CH3:17][C:18]1([CH3:37])[C:27]2[CH:26]=[C:25](B3OC(C)(C)C(C)(C)O3)[CH:24]=[CH:23][C:22]=2[CH2:21][CH2:20][CH2:19]1.Cl>>[CH3:17][C:18]1([CH3:37])[C:27]2[CH:26]=[C:25]([C:2]3[N:3]=[C:4]([N:7]4[CH2:12][CH2:11][CH:10]([NH:13][CH2:14][CH2:15][OH:16])[CH2:9][CH2:8]4)[S:5][CH:6]=3)[CH:24]=[CH:23][C:22]=2[CH2:21][CH2:20][CH2:19]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 532501142-(8,8-Dimethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolaneHCID 673233402-(1-(4-Bromothiazol-2-yl)piperidin-4-ylamino)ethanol

Product 1

HCID 673238212-{1-[4-(8,8-Dimethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]piperidin-4-ylamino}ethanol

Procedure

The preparation is carried out as described above starting from 100 mg (0.27 mmol) of 2-[1-(4-bromothiazol-2-yl)piperidin-4-ylamino]ethanol and 98 mg (0.30 mmol) of 2-(8,8-dimethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane. The product is in the form of the hydrochloride.

Sources & evidence

ORD record
ord-0854d889772b42f7b0b2f67ffc2a76a0
Source dataset
uspto-grants-2014_12
Patent number
US08907098B2

Reaction notes

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