HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Morpholine-2-carboxylic acid [6-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)pyridin-2-yl]amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 2-[6-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)pyridin-2-ylcarbamoyl]morpholine-4-carboxylic acid tert-butyl ester | HCID 67323275 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Morpholine-2-carboxylic acid [6-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)pyridin-2-yl]amide | HCID 67249005 | — |
Reaction Steps
The protecting group is cleaved off as already described using TFA in DCM starting from 92 mg (0.19 mmol) of 2-[6-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)pyridin-2-ylcarbamoyl]morpholine-4-carboxylic acid tert-butyl ester from step b. The product is purified by means of preparative HPLC and is in the form of the TFA salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08907098B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-c9637eb2815a459eaea54e75fd37a05e |
| Source note | uspto-grants-2014_12 |