反应详情

To a solution of N-methylbenzoselenohydrazide (215 mg, 1.0 mmol) and malonic acid (53 mg, 0.5 mmol) in CH2Cl2 (5 mL), was added EDC (240 mg, 1.25 mmol). The mixture was stirred for 1 h at RT. The reaction mixture was diluted with CH2Cl2 (15 mL) and washed with water and brine. The organic layer was dried over MgSO4 and filtered. After removal of the solvent, the product was purified by chromatography column on silica gel (1:1 Hexane:EtOAc and EtOAc) and to give (N′1,N′3-dimethyl-N′1,N′3-di(phenylcarbonoselenoyl)malonohydrazide (Compound 1), 188 mg in 76% yield.

1. washwashed with water and brine
2. dry with materialThe organic layer was dried over MgSO4
3. filtrationfiltered
4. customAfter removal of the solvent
5. customthe product was purified by chromatography column on silica gel (1:1 Hexane:EtOAc and EtOAc)