Hydrochloric Acid → HCID 68571720, compound

HRID 1401887Notes

Reaction equation

HRID 1401887 reaction equation
C([O:5][C:6](=[O:48])[C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH:14]([C:32]2[CH:37]=[CH:36][C:35]([C:38]3[CH2:43][CH2:42][C@@H:41]([C:44]([CH3:47])([CH3:46])[CH3:45])[CH2:40][CH:39]=3)=[CH:34][CH:33]=2)[C:15](=[O:31])[NH:16][C:17]2[CH:22]=[CH:21][C:20]([C:23]3[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][C:24]=3[CH3:30])=[CH:19][CH:18]=2)=[CH:9][CH:8]=1)(C)(C)C.Cl.O1CCOCC1.Cl>O>[C:44]([C@@H:41]1[CH2:42][CH2:43][C:38]([C:35]2[CH:34]=[CH:33][C:32]([CH:14]([C:15](=[O:31])[NH:16][C:17]3[CH:18]=[CH:19][C:20]([C:23]4[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][C:24]=4[CH3:30])=[CH:21][CH:22]=3)[CH2:13][C:10]3[CH:11]=[CH:12][C:7]([C:6]([OH:48])=[O:5])=[CH:8][CH:9]=3)=[CH:37][CH:36]=2)=[CH:39][CH2:40]1)([CH3:47])([CH3:46])[CH3:45]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 204431481,4-Dioxane hydrochlorideHCID 67211736HCID 67211736, compound

Product 1

HCID 68571720HCID 68571720, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 4-{2-[4-(4-(R)-tert-Butylcyclohex-1-enyl)-phenyl]-2-(4′-chloro-2′-methylbiphenyl-4-ylcarbamoyl)-ethyl]-benzoic acid tert-butyl ester (727 mg, 1.1 mmol) was added 4N HCl/dioxane (30 mL), water (5 mL) and conc. HCl (1 mL). The resulting solution was stirred at rt overnight. The excess solvent was removed under vacuum and the residue co-evaporated with toluene to afford the desired crude product as a gummy oil. The crude material was used the next step without further purification.

Workup

  1. customThe excess solvent was removed under vacuum

Sources & evidence

ORD record
ord-480c4c30dd8742b8b66652c18758aae2
Source dataset
uspto-grants-2014_12
Patent number
US08907103B2

Reaction notes

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