Hydrogen Bromide → HCID 66905881, compound

HRID 1401973Notes

Reaction equation

HRID 1401973 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:14]C)=[C:6]([CH:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:7]=1.[BrH:16]>>[BrH:16].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:14])=[C:6]([CH:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)[CH:7]=1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 497608164-(5-Chloro-2-methoxyphenyl)piperidine

Product 1

HCID 66905881HCID 66905881, compoundYield 97%

Procedure

To 4-(5-chloro-2-methoxyphenyl)piperidine (Preparation 233, 40 g, 0.177 mol) was added hydrogen bromide (48% in water, 100 ml) and refluxed for 24 hours before concentrating in vacuo. 1,4-Dioxane was added and solution concentrated in vacuo. The resulting crystals were washed with diethyl ether and dried in vacuo to give the title compound as white crystals, 53 g, 97% yield.

Workup

  1. temperaturerefluxed for 24 hours
  2. concentrationbefore concentrating in vacuo
  3. addition1,4-Dioxane was added
  4. concentrationsolution concentrated in vacuo
  5. washThe resulting crystals were washed with diethyl ether
  6. customdried in vacuo

Sources & evidence

ORD record
ord-7ef3e885c5d245d2ae4b5deef1a35e23
Source dataset
uspto-grants-2014_12
Patent number
US08907101B2

Reaction notes

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