反应详情

To 4-(5-chloro-2-methoxyphenyl)piperidine (Preparation 233, 40 g, 0.177 mol) was added hydrogen bromide (48% in water, 100 ml) and refluxed for 24 hours before concentrating in vacuo. 1,4-Dioxane was added and solution concentrated in vacuo. The resulting crystals were washed with diethyl ether and dried in vacuo to give the title compound as white crystals, 53 g, 97% yield.

1. temperaturerefluxed for 24 hours
2. concentrationbefore concentrating in vacuo
3. addition1,4-Dioxane was added
4. concentrationsolution concentrated in vacuo
5. washThe resulting crystals were washed with diethyl ether
6. customdried in vacuo