Isopropyl isocyanate → HCID 86686959, compound

HRID 1402096Notes

Reaction equation

HRID 1402096 reaction equation
[CH:1]([N:4]=[C:5]=[O:6])([CH3:3])[CH3:2].[F:7][C:8]1[CH:9]=[CH:10][C:11]([NH:14][NH2:15])=[N:12][CH:13]=1>C(Cl)Cl>[F:7][C:8]1[CH:9]=[CH:10][C:11]([NH:14][NH:15][C:5]([NH:4][CH:1]([CH3:3])[CH3:2])=[O:6])=[N:12][CH:13]=1

Participants

4

Reactant 2

HCID 61277Isopropyl isocyanateHCID 199167865-Fluoro-2-hydrazinylpyridine

Product 1

HCID 86686959HCID 86686959, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Isopropyl isocyanate (0.25 mL, 2.60 mmol) was added dropwise, over 2 min, to a solution of 5-fluoro-2-hydrazinyl-pyridine (for reference procedure see WO 2010/022076, which is incorporated herein by reference in its entirety; 0.30 g, 2.36 mmol) in dry DCM (10 mL) at RT and stirred for 3 h. The solvent was evaporated and the residue triturated (diethyl ether) and filtered to give the title compound as a colourless solid (464 mg, 93%). LCMS (Method 1): Rt 1.92 min, m/z 213 [MH+].

Workup

  1. customThe solvent was evaporated
  2. customthe residue triturated (diethyl ether)
  3. filtrationfiltered

Sources & evidence

ORD record
ord-9881a1987c6f499f8696118473f81b87
Source dataset
uspto-grants-2014_12
Patent number
US08907094B2

Reaction notes

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