Bromotrimethylsilane → HCID 67450329, compound

HRID 1402652Notes

Reaction equation

HRID 1402652 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([P:8]([C:13]2([C:16]#[N:17])[CH2:15][CH2:14]2)(=[O:12])[O:9]CC)=[CH:4][CH:3]=1.Br[Si](C)(C)C>C(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([P:8]([C:13]2([C:16]#[N:17])[CH2:14][CH2:15]2)(=[O:9])[OH:12])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 76113BromotrimethylsilaneHCID 86659553HCID 86659553, compound

Product 1

HCID 67450329HCID 67450329, compoundYield 111.7%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

0.150 g (0.556 mmol) of ethyl (4-chlorophenyl)(1-cyanocyclopropyl)phosphinate was dissolved in 20 ml of chloroform, and 0.511 g (3.337 mmol) of bromotrimethylsilane was added. After stirring at room temperature for 18 hours, the solvent was removed, the residue was taken up in water and the solution was concentrated again by rotary evaporation. After column chromatography, 0.150 g (94.9% of theory) of (4-chlorophenyl)(1-cyanocyclopropyl)phosphinic acid was obtained.

Workup

  1. customthe solvent was removed
  2. concentrationthe solution was concentrated again by rotary evaporation

Sources & evidence

ORD record
ord-02f47e3468374d1ea520a49401c0a2c9
Source dataset
uspto-grants-2014_12
Patent number
US08912124B2

Reaction notes

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